Correlative studies in neuro-oncology trials: should they influence treatment?

Details

Serval ID
serval:BIB_A45CE919025A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Correlative studies in neuro-oncology trials: should they influence treatment?
Journal
Current Oncology Reports
Author(s)
Hegi M.E., Stupp R.
ISSN
1523-3790 (Print)
ISSN-L
1523-3790
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
8
Number
1
Pages
54-57
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Recent molecular correlative studies accompanying clinical trials in glioma have provided strong evidence for prognostic markers and predictive factors for treatment response. However, to what extent can these markers influence the limited choice of therapeutic options? Do we further validate the markers in the next trials or move on, incorporate the markers for patient selection or stratification, aim at improving the modestly effective treatments by adding new drugs, and develop alternative therapy strategies for patients selected for their bad predictor?
Keywords
Brain Neoplasms/genetics, Brain Neoplasms/metabolism, Clinical Trials as Topic/methods, Female, Glioma/genetics, Glioma/metabolism, Humans, Male, Prognosis, Tumor Markers, Biological/genetics, Tumor Markers, Biological/metabolism
Pubmed
Create date
28/01/2008 8:39
Last modification date
20/08/2019 15:09
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