Association between smoking and recurrence of venous thromboembolism and bleeding in elderly patients with past acute venous thromboembolism.

Détails

Ressource 1Télécharger: BIB_A42C877CEFEB.P001.pdf (1019.10 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_A42C877CEFEB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between smoking and recurrence of venous thromboembolism and bleeding in elderly patients with past acute venous thromboembolism.
Périodique
Thrombosis Research
Auteur(s)
Carruzzo P., Méan M., Limacher A., Aujesky D., Cornuz J., Clair C.
ISSN
1879-2472 (Electronic)
ISSN-L
0049-3848
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
138
Pages
74-79
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
BACKGROUND: While the association between smoking and arterial cardiovascular events has been well established, the association between smoking and venous thromboembolism (VTE) remains controversial.
OBJECTIVES: To assess the association between smoking and the risk of recurrent VTE and bleeding in patients who have experienced acute VTE.
PATIENTS/METHODS: This study is part of a prospective Swiss multicenter cohort that included patients aged ≥65years with acute VTE. Three groups were defined according to smoking status: never, former and current smokers. The primary outcome was the time to a first symptomatic, objectively confirmed VTE recurrence. Secondary outcomes were the time to a first major and clinically relevant non-major bleeding. Associations between smoking status and outcomes were analysed using proportional hazard models for the subdistribution of a competing risk of death.
RESULTS: Among 988 analysed patients, 509 (52%) had never smoked, 403 (41%) were former smokers, and 76 (8%) current smokers. After a median follow-up of 29.6months, we observed a VTE recurrence rate of 4.9 (95% confidence interval [CI] 3.7-6.4) per 100 patient-years for never smokers, 6.6 (95% CI 5.1-8.6) for former smokers, and 5.2 (95% CI 2.6-10.5) for current smokers. Compared to never smokers, we found no association between current smoking and VTE recurrence (adjusted sub-hazard ratio [SHR] 1.05, 95% CI 0.49-2.28), major bleeding (adjusted SHR 0.59, 95% CI 0.25-1.39), and clinically relevant non-major bleeding (adjusted SHR 1.21, 95% CI 0.73-2.02).
CONCLUSIONS: In this multicentre prospective cohort study, we found no association between smoking status and VTE recurrence or bleeding in elderly patients with VTE.
Mots-clé
Acute Disease, Aged, Aged, 80 and over, Female, Hemorrhage/etiology, Hemorrhage/pathology, Humans, Male, Prospective Studies, Recurrence, Risk Factors, Smoking/adverse effects, Venous Thromboembolism/etiology, Venous Thromboembolism/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/01/2016 11:21
Dernière modification de la notice
16/10/2019 16:18
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