Serious or fatal accidents during fluorescein angiography were assessed by an international survey involving answers from 260 clinics in 30 different countries in respect of 594, 687 angiographies. Incidence of fatal accidents was one case per 49,557 angiographies, and of serious accidents, one case per 18,020 angiographies. The total number of accidents reported was 45 cases, equal to one case per 13,215 angiographies. Age, general health of the patients, and the experience of the different clinics who perform this examination, seem to influence the occurrence and the seriousness of these accidents.