HLA association of amoxicillin-clavulanate--induced hepatitis.

Détails

ID Serval
serval:BIB_A4184B36208B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
HLA association of amoxicillin-clavulanate--induced hepatitis.
Périodique
Gastroenterology
Auteur(s)
Hautekeete M.L., Horsmans Y., Van Waeyenberge C., Demanet C., Henrion J., Verbist L., Brenard R., Sempoux C., Michielsen P.P., Yap P.S., Rahier J., Geubel A.P.
ISSN
0016-5085 (Print)
ISSN-L
0016-5085
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
117
Numéro
5
Pages
1181-1186
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND & AIMS: Drug-induced immunoallergic hepatitis typically affects a minority of patients exposed to a particular drug. Its rarity is believed to be due to metabolic or immunologic idiosyncrasy. The presence of an immunologic idiosyncrasy might imply an HLA association. Previous studies reporting an HLA association of drug-induced hepatitis included only small numbers of patients and used serological HLA typing.
METHODS: We studied 35 patients with biopsy-documented amoxicillin-clavulanate-induced hepatitis. HLA-A and -B were typed using alloantisera and compared with those of 300 controls (volunteer bone marrow donors). HLA-DRB and -DWB were typed by polymerase chain reaction-line probe assay, with 60 volunteer bone marrow donors serving as controls.
RESULTS: The study group was characterized by a higher frequency of DRB1*1501-DRB5*0101-DQB1*0602 haplotype (57.1% vs. 11.7% in controls, P < 0.000005; after correction for the large number of comparisons, P < 0.0002). Patients with DRB1*1501-DRB5*0101-DQB1*0602 haplotype were more likely than patients without it to have a cholestatic (70% vs. 60%) or mixed (30% vs. 13%) than a hepatocellular pattern of hepatitis (0% vs. 27%) (P < 0.05).
CONCLUSIONS: Amoxicillin-clavulanate-induced hepatitis is associated with the DRB1*1501-DRB5*0101-DQB1*0602 haplotype. The data support the view that an immunologic idiosyncrasy, mediated through HLA class II antigens, plays a role in the pathogenesis of drug-induced immunoallergic hepatitis. HLA association has a limited impact on the expression of hepatitis.
Mots-clé
Adult, Aged, Aged, 80 and over, Amoxicillin/adverse effects, Clavulanic Acid/adverse effects, Drug-Induced Liver Injury/immunology, Female, HLA-DQ Antigens/genetics, HLA-DQ beta-Chains, HLA-DR Antigens/genetics, HLA-DRB1 Chains, HLA-DRB5 Chains, Haplotypes, Histocompatibility Antigens Class II/analysis, Humans, Male, Middle Aged
Pubmed
Web of science
Création de la notice
20/10/2016 17:36
Dernière modification de la notice
03/03/2018 20:13
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