The human K-complex represents an isolated cortical down-state.

Details

Serval ID
serval:BIB_A3C624C47D72
Type
Article: article from journal or magazin.
Collection
Publications
Title
The human K-complex represents an isolated cortical down-state.
Journal
Science
Author(s)
Cash S.S., Halgren E., Dehghani N., Rossetti A.O., Thesen T., Wang C., Devinsky O., Kuzniecky R., Doyle W., Madsen J.R., Bromfield E., Eross L., Halász P., Karmos G., Csercsa R., Wittner L., Ulbert I.
ISSN
1095-9203[electronic]
Publication state
Published
Issued date
2009
Volume
324
Number
5930
Pages
1084-1087
Language
english
Abstract
The electroencephalogram (EEG) is a mainstay of clinical neurology and is tightly correlated with brain function, but the specific currents generating human EEG elements remain poorly specified because of a lack of microphysiological recordings. The largest event in healthy human EEGs is the K-complex (KC), which occurs in slow-wave sleep. Here, we show that KCs are generated in widespread cortical areas by outward dendritic currents in the middle and upper cortical layers, accompanied by decreased broadband EEG power and decreased neuronal firing, which demonstrate a steep decline in network activity. Thus, KCs are isolated "down-states," a fundamental cortico-thalamic processing mode already characterized in animals. This correspondence is compatible with proposed contributions of the KC to sleep preservation and memory consolidation.
Pubmed
Web of science
Create date
26/05/2009 7:10
Last modification date
20/08/2019 15:09
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