Intrachannel versus interchannel application of angiogenic factors in transmyocardial laser revascularization.

Détails

ID Serval
serval:BIB_A3BA7463D196
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Intrachannel versus interchannel application of angiogenic factors in transmyocardial laser revascularization.
Périodique
Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera
Auteur(s)
Mueller X.M., Tevaearai H.T., Genton C.Y., Chaubert P., von Segesser L.K.
ISSN
0007-1323
1023-9332
Statut éditorial
Publié
Date de publication
2001
Volume
7
Numéro
3
Pages
116-20
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article - Publication Status: ppublish
Résumé
BACKGROUND AND OBJECTIVE: Theoretically myocardial angiogenesis of laser injury can be further enhanced by the addition of angiogenic growth factors. The influence of the way of administration of these factors on vascular growth around the channels is still unclear. MATERIALS AND METHODS: 18 pigs (mean weight 72 +/- 5.2 kg) were randomized to either triads of transmyocardial laser revascularization (TMLR) channels (group 1, n = 6) or isolated channels (group 2, n = 6), or a control group (n = 6). The animals had injections of bovine bone derived growth factor mixture either in the center of the triads in group 1 or within the channels themselves in group 2. Animals were sacrificed one month later for histological analysis. RESULTS: The vascular densities of myocardial areas within the triads of group 1 and around the channels in group 2 were significantly larger than in the control group: 15.2 +/- 3.7/mm2 and 14.2 +/- 3.5/mm2 respectively vs 5.3 +/- 1.6/mm2 (p < 0.001 for both differences). Differences of densities between group 1 and 2 were not statistically significant (p = 0.6). CONCLUSIONS: In this porcine model, the addition of a bovine bone derived growth factor mixture to TMLR significantly stimulates angiogenesis in the areas adjacent to the channels. The place of injection does not influence the angiogenesis intensity.
Mots-clé
Angiogenesis Inducing Agents, Animals, Coronary Vessels, Drug Combinations, Growth Substances, Heart Ventricles, Injections, Laser Therapy, Myocardial Revascularization, Neovascularization, Physiologic, Swine
Pubmed
Création de la notice
14/02/2008 15:16
Dernière modification de la notice
03/03/2018 20:12
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