Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent.

Details

Serval ID
serval:BIB_A3ADE8ED294E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent.
Journal
World journal of urology
Author(s)
Mbeutcha A., Lucca I., Margulis V., Karam J.A., Wood C.G., de Martino M., Mathieu R., Haitel A., Xylinas E., Kluth L., Rouprêt M., Karakiewicz P.I., Briganti A., Rink M., Rieken M., Weizer A.Z., Raman J.D., Rioux-Leclecq N., Bolenz C., Bensalah K., Lotan Y., Seitz C., Remzi M., Shariat S.F., Klatte T.
ISSN
1433-8726 (Electronic)
ISSN-L
0724-4983
Publication state
Published
Issued date
08/2016
Peer-reviewed
Oui
Volume
34
Number
8
Pages
1155-1161
Language
english
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Abstract
Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.
Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.
ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).
ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.

Keywords
Aged, Carcinoma, Transitional Cell/metabolism, Carcinoma, Transitional Cell/mortality, Carcinoma, Transitional Cell/surgery, DNA-Binding Proteins/biosynthesis, Endonucleases/biosynthesis, Female, Humans, Kidney Neoplasms/metabolism, Kidney Neoplasms/mortality, Kidney Neoplasms/surgery, Male, Middle Aged, Nephrectomy, Prognosis, Retrospective Studies, Survival Rate, Ureter/surgery, Ureteral Neoplasms/metabolism, Ureteral Neoplasms/mortality, Ureteral Neoplasms/surgery, Urologic Neoplasms
Pubmed
Web of science
Create date
11/10/2016 15:30
Last modification date
20/08/2019 15:09
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