Advances and Applications in the Quest for Orthologs.

Détails

ID Serval
serval:BIB_A36FE75880A9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Advances and Applications in the Quest for Orthologs.
Périodique
Molecular biology and evolution
Auteur(s)
Glover N., Dessimoz C., Ebersberger I., Forslund S.K., Gabaldón T., Huerta-Cepas J., Martin M.J., Muffato M., Patricio M., Pereira C., da Silva A.S., Wang Y., Sonnhammer E., Thomas P.D.
Contributeur(s)
Altenhoff A., Blake J.A., Capella-Gutierrez S., Chiba H., Dessimoz C., Durand D., Ebersberger I., Tomás Fernández-Breis J., Forslund S., Gabaldon T., Glover N., Huerta-Cepas J., Lecompte O., Lewis S., Linard B., Marcet Houben M., Marcotte E.M., Martin M.J., McWhite C., Mendes de Farias T., Muffato M., Nevers Y., Patricio M., Pereira C., Pryszcz L., Saha S., Schiffer P., Sonnhammer E., Sousa da Silva A., Tang H., Thomas P.D., Uchiyama I., Wang Y.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Statut éditorial
Publié
Date de publication
01/10/2019
Peer-reviewed
Oui
Volume
36
Numéro
10
Pages
2157-2164
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
Gene families evolve by the processes of speciation (creating orthologs), gene duplication (paralogs), and horizontal gene transfer (xenologs), in addition to sequence divergence and gene loss. Orthologs in particular play an essential role in comparative genomics and phylogenomic analyses. With the continued sequencing of organisms across the tree of life, the data are available to reconstruct the unique evolutionary histories of tens of thousands of gene families. Accurate reconstruction of these histories, however, is a challenging computational problem, and the focus of the Quest for Orthologs Consortium. We review the recent advances and outstanding challenges in this field, as revealed at a symposium and meeting held at the University of Southern California in 2017. Key advances have been made both at the level of orthology algorithm development and with respect to coordination across the community of algorithm developers and orthology end-users. Applications spanned a broad range, including gene function prediction, phylostratigraphy, genome evolution, and phylogenomics. The meetings highlighted the increasing use of meta-analyses integrating results from multiple different algorithms, and discussed ongoing challenges in orthology inference as well as the next steps toward improvement and integration of orthology resources.
Mots-clé
gene family, genome evolution, orthology
Pubmed
Open Access
Oui
Création de la notice
08/07/2019 16:09
Dernière modification de la notice
23/10/2019 5:13
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