Associations of serum EBV DNA and gammopathy with post-transplant lymphoproliferative disease.

Détails

ID Serval
serval:BIB_A35C2CDCD130
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Associations of serum EBV DNA and gammopathy with post-transplant lymphoproliferative disease.
Périodique
Clinical Transplantation
Auteur(s)
Rosselet A., Vu D.H., Meylan P., Chaubert A.S., Schapira M., Pascual M., Aubert V., Tissot J.D., Duchosal M.A.
ISSN
1399-0012[electronic], 0902-0063[linking]
Statut éditorial
Publié
Date de publication
2009
Volume
23
Numéro
1
Pages
74-82
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
BACKGROUND: Post-transplant lymphoproliferative disease (PTLD) is a life-threatening complication of immunosuppression following transplantation. Epstein-Barr virus (EBV) and gammopathy in serum are associated with PTLD, but these two parameters have not been evaluated in parallel for their association with PTLD. METHODS: We evaluated the incidence of EBV load positivity, gammopathy, and protein expression in sera from all PTLD patients diagnosed at our hospital during the past seven yr. Results were compared with those of a control group including matched transplanted patients who did not develop PTLD. RESULTS: Seven of 10 PTLD patients presented EBV(+) PTLD, for which five patients had detectable serum EBV DNA levels compared with none of 38 controls (RR between two groups =121, p < 0.0001). Five out of 10 patients had gammopathy at PTLD diagnosis compared with 5/38 controls (RR between two groups = 6.6, p = 0.022). Additionally, protein serum analysis by high-resolution two-dimensional gel electrophoresis and image examination failed to evidence specific abnormality in patients with PTLD compared with controls. CONCLUSIONS: Our results confirm an association between EBV in sera and gammopathy with PTLD, and highlight the high specificity of the former analysis. Whether a combination of both analyses will improve the clinical detection of PTLD remains to be evaluated in a larger prospective cohort study.
Mots-clé
Adolescent, Adult, Aged, DNA, Viral/blood, DNA, Viral/genetics, Electrophoresis, Gel, Two-Dimensional, Epstein-Barr Virus Infections/virology, Female, Herpesvirus 4, Human/isolation &amp, purification, Humans, Immunosuppressive Agents/adverse effects, In Situ Hybridization, Incidence, Kidney Transplantation, Lymphoproliferative Disorders/blood, Lymphoproliferative Disorders/etiology, Male, Middle Aged, Paraproteinemias/complications, Retrospective Studies, Sensitivity and Specificity, Transplantation, Homologous, Viral Load, Young Adult
Pubmed
Web of science
Création de la notice
25/03/2009 9:58
Dernière modification de la notice
20/08/2019 15:09
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