Emerging roles of A-kinase anchoring proteins in cardiovascular pathophysiology

Détails

ID Serval
serval:BIB_A31F70F45283
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Emerging roles of A-kinase anchoring proteins in cardiovascular pathophysiology
Périodique
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Auteur(s)
Diviani Dario, Reggi Erica, Arambasic Miroslav, Caso Stefania, Maric Darko
ISSN
0167-4889
ISSN-L
1879-2596
Statut éditorial
Publié
Date de publication
07/2016
Peer-reviewed
Oui
Volume
1863
Numéro
7
Pages
1926-1936
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Heart and blood vessels ensure adequate perfusion of peripheral organs with blood and nutrients. Alteration of the homeostatic functions of the cardiovascular system can cause hypertension, atherosclerosis, and coronary artery disease leading to heart injury and failure. A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that are crucially involved in modulating the function of the cardiovascular system both under physiological and pathological conditions. AKAPs assemble multifunctional signaling complexes that ensure correct targeting of the cAMP-dependent protein kinase (PKA) as well as other signaling enzymes to precise subcellular compartments. This allows local regulation of specific effector proteins that control the function of vascular and cardiac cells. This review will focus on recent advances illustrating the role of AKAPs in cardiovascular pathophysiology. The accent will be mainly placed on the molecular events linked to the control of vascular integrity and blood pressure as well as on the cardiac remodeling process associated with heart failure. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
Mots-clé
A Kinase Anchor Proteins/metabolism, Cyclic AMP-Dependent Protein Kinases/metabolism, Heart Failure/enzymology, Heart Failure/pathology, Heart Failure/physiopathology, Muscle, Smooth, Vascular/enzymology, Muscle, Smooth, Vascular/pathology, Muscle, Smooth, Vascular/physiopathology, Myocytes, Cardiac/enzymology, Myocytes, Cardiac/pathology, Myocytes, Smooth Muscle/enzymology, Myocytes, Smooth Muscle/pathology, Cell Biology, Molecular Biology
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/10/2016 15:29
Dernière modification de la notice
20/08/2019 15:08
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