Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery.
Details
Serval ID
serval:BIB_A31F52F6B456
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery.
Journal
Immunity
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
2008
Volume
28
Number
6
Pages
870-880
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and control autoimmunity through a cell-contact-dependent mechanism. We found two subsets of FOXP3+ natural Treg cells defined by the expression of the costimulatory molecule ICOS in the human thymus and periphery. Whereas the ICOS+FOXP3+ Treg cells used interleukin-10 to suppress dendritic cell function and transforming growth factor (TGF)-beta to suppress T cell function, the ICOS-FOXP3+ Treg cells used TGF-beta only. The survival and proliferation of the two subsets of Treg cells were differentially regulated by signaling through ICOS or CD28, respectively. We suggest that the selection of natural Treg cells in thymus is coupled with Treg cell differentiation into two subsets imprinted with different cytokine expression potentials and use both cell-contact-dependent and independent mechanisms for immunosuppression in periphery.
Keywords
Antigens, CD28/metabolism, Antigens, Differentiation, T-Lymphocyte/immunology, Antigens, Differentiation, T-Lymphocyte/metabolism, Cell Proliferation, Cell Survival, Cells, Cultured, Dendritic Cells/immunology, Dendritic Cells/metabolism, Forkhead Transcription Factors/metabolism, Humans, Inducible T-Cell Co-Stimulator Protein, Interleukin-10/immunology, Interleukin-10/metabolism, Signal Transduction, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, T-Lymphocytes, Regulatory/cytology, T-Lymphocytes, Regulatory/immunology, Thymus Gland/cytology, Thymus Gland/immunology, Transforming Growth Factor beta/immunology, Transforming Growth Factor beta/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2012 19:48
Last modification date
20/08/2019 16:08
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