Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study.

Détails

ID Serval
serval:BIB_A2D63B38436E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study.
Périodique
Journal of Clinical Pharmacology
Auteur(s)
Panchaud A., Csajka C., Merlob P., Schaefer C., Berlin M., De Santis M., Vial T., Ieri A., Malm H., Eleftheriou G., Stahl B., Rousso P., Winterfeld U., Rothuizen L.E., Buclin T.
ISSN
1552-4604 (Electronic)
ISSN-L
0091-2700
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
52
Numéro
12
Pages
1844-1851
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Concerns have been raised about the use of topical retinoids since the publication of isolated cases of characteristic retinoid embryopathy, originally described after oral use. A collaborative study of the European Network of Teratology Information Services was carried out to evaluate the rate of congenital malformations following first-trimester topical retinoid exposure. A population of 235 exposed pregnant women was compared with 444 controls. No significant differences were observed between groups with regard to the rates of spontaneous abortion (odds ratio [95% confidence interval], 1.5 [0.8-2.7]), minor birth defects (1.3 [0.4-3.7]), and major birth defects (1.8 [0.6-5.4]). No child showed features of retinoid embryopathy. The rate of elective termination in the exposed group was increased 3-fold (3.4 [1.5-7.8]). In conclusion, these results do not suggest an increased risk of retinoid embryopathy. However, according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable.
Pubmed
Web of science
Création de la notice
20/10/2011 16:03
Dernière modification de la notice
03/03/2018 20:10
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