Gout: new insights into an old disease.

Détails

ID Serval
serval:BIB_A285918E78E3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Titre
Gout: new insights into an old disease.
Périodique
Journal of Clinical Investigation
Auteur(s)
Martinon F., Glimcher L.H.
ISSN
0021-9738 (Print)
ISSN-L
0021-9738
Statut éditorial
Publié
Date de publication
2006
Volume
116
Numéro
8
Pages
2073-2075
Langue
anglais
Résumé
Gout is an autoinflammatory disorder associated with deposition of monosodium urate (MSU) crystals in joints and periarticular tissues. Recent advances suggest that the innate immune system may drive the gouty inflammatory response to MSU. These findings prompt questions concerning how the innate immune system recognizes MSU and the identities of the receptors involved. In this issue of the JCI, Chen et al. show that the IL-1 receptor and its signaling protein myeloid differentiation primary response protein 88 (MyD88) but not the "classical" innate immune receptors, TLRs, are central for MSU-induced inflammation (see the related article beginning on page 2262).
Mots-clé
Adaptor Proteins, Signal Transducing/physiology, Gout/immunology, Gout/physiopathology, Humans, Inflammation/immunology, Inflammation/physiopathology, Models, Biological, Myeloid Differentiation Factor 88
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/02/2011 16:36
Dernière modification de la notice
08/05/2019 23:02
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