Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography.

Détails

ID Serval
serval:BIB_A2766E2F9EE1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography.
Périodique
Osteoarthritis and cartilage
Auteur(s)
Omoumi P., Babel H., Jolles B.M., Favre J.
ISSN
1522-9653 (Electronic)
ISSN-L
1063-4584
Statut éditorial
Publié
Date de publication
04/2019
Peer-reviewed
Oui
Volume
27
Numéro
4
Pages
621-629
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To test whether subchondral bone mineral density (sBMD) and cartilage thickness (CTh) of femoral condyles are correlated in knees without and with severe medial femorotibial osteoarthritis (OA), using a subregional analysis with computerized tomography (CT) arthrography.
CT arthrograms of 50 non-OA (18 males, 58.7 (interquartile range (IQR) = 6.6 years)) and 50 severe medial OA (24 males, 60.5 (IQR = 10.7) years) knees, were retrospectively analyzed. Bone and cartilage were segmented using custom-designed software, leading to 3D models on which each point of the subchondral surface is given a CTh and sBMD value. The average sBMD and CTh were then calculated for the entire weight-bearing regions as well as specific subregions of interest. Linear bivariate and multivariable analyses were performed to test for relationships between sBMD and CTh (regional and subregional measures, or medial-to-lateral ratios), with confounders of age, gender, femoral bone size and femorotibial angle.
In non-OA knees, the sBMD and CTh medial-to-lateral ratios were positively correlated for the total region and the external and internal subregions (r ≥ 0.341, P ≤ 0.015). In OA knees, sBMD and CTh medial-to-lateral ratios were negatively correlated for the total region and the external and central subregions (r ≤ -0.538, P < 0.001). Additional positive/negative relationships in the non-OA/OA knees were observed between sBMD and CTh measures in the medial compartment.
The positive correlation between sBMD and CTh in non-OA knees, and the negative one in OA knees, bring support to the theory of a subchondral bone/cartilage functional unit, which could help to better understand the pathophysiology of OA.
Mots-clé
Bone mineral, CT arthrography, Cartilage thickness, Density, Osteoarthritis, Subchondral bone
Pubmed
Web of science
Création de la notice
04/02/2019 11:34
Dernière modification de la notice
20/08/2019 16:08
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