The SLC2 (GLUT) family of membrane transporters.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_A2607C275E16
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The SLC2 (GLUT) family of membrane transporters.
Périodique
Molecular Aspects of Medicine
Auteur(s)
Mueckler M., Thorens B.
ISSN
1872-9452 (Electronic)
ISSN-L
0098-2997
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
34
Numéro
2-3
Pages
121-138
Langue
anglais
Résumé
GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into three classes based on sequence similarity. All GLUTs appear to transport hexoses or polyols when expressed ectopically, but the primary physiological substrates for several of the GLUTs remain uncertain. GLUTs 1-5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of ∼500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains. In this review we briefly describe the major characteristics of the 14 GLUT family members.
Mots-clé
SLC2, GLUT, Membrane transport, Glucose transporters, Glucose homeostasis
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/05/2013 14:15
Dernière modification de la notice
08/05/2019 23:02
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