Visuelle Ergebnisse der fraktionierten Strahlentherapie beim Sehnervenscheidenmeningeom: eine retrospektive Studie [Visual Outcomes of Fractionated Radiotherapy in Optic Nerve Sheath Meningioma: A Retrospective Study]

Détails

ID Serval
serval:BIB_A236B26AFA24
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Visuelle Ergebnisse der fraktionierten Strahlentherapie beim Sehnervenscheidenmeningeom: eine retrospektive Studie [Visual Outcomes of Fractionated Radiotherapy in Optic Nerve Sheath Meningioma: A Retrospective Study]
Périodique
Klinische Monatsblatter fur Augenheilkunde
Auteur(s)
Kheir V., Faouzi M., Borruat F.X.
ISSN
1439-3999 (Electronic)
ISSN-L
0023-2165
Statut éditorial
Publié
Date de publication
04/2019
Peer-reviewed
Oui
Volume
236
Numéro
4
Pages
526-529
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Optic nerve sheath meningioma (ONSM) is a rare benign tumour of the optic nerve sheath that can lead to blindness if untreated. Radiotherapy is commonly accepted as being the treatment of choice. We conducted a retrospective monocentric study to assess the effect of radiotherapy on visual outcomes and tumour control in patients with ONSM.
The charts of all patients affected by ONSM between 1994 and 2016 were reviewed retrospectively. Inclusion criteria were: having been followed by our department, initial visual acuity (VA) better than no light perception, and stereotactic fractionated radiotherapy. VA (Snellen), colour vision (Ishihara), and visual field mean defect (in dB), as well as ONSM size (on MRI) were compared before and after radiotherapy. Visual function was considered improved if two or more criteria improved, stabilised if none or only one criterion changed, and worsened if two or more criteria worsened. The Wilcoxon signed-rank test was used to assess the effect of radiotherapy (significant if p value < 0.05).
VA improved or stabilised in 13/16 patients (81.25%), with median VA improving from 0.1 logMAR (8/10) to 0 logMAR (10/10) (p value = 0.0134). Colour vision improved or stabilised in 11/15 patients (73.33%), with median results improving from 5/13 to 12/13 (p value = 0.3212). The visual field mean defect improved in 13/15 patients (86.66%), and the median mean defect (MD) improved from 10 dB to 4 dB (p value = 0.0106). The size of the ONSM diminished or stabilised in 100% of our patients. No adverse events of radiotherapy were either reported or detected.
Fractionated radiotherapy is a safe procedure and may improve visual function in patients with ONSM.
Mots-clé
optic nerve sheath meningioma - radiotherapy - visual function
Pubmed
Web of science
Création de la notice
12/03/2019 9:41
Dernière modification de la notice
20/08/2019 15:08
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