Paradigms of notch signaling in mammals.

Détails

ID Serval
serval:BIB_A21182604351
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Paradigms of notch signaling in mammals.
Périodique
International journal of hematology
Auteur(s)
Dumortier A., Wilson A., MacDonald H.R., Radtke F.
ISSN
0925-5710
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
82
Numéro
4
Pages
277-284
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. These proteins are involved in organogenesis during embryonic development as well as in the maintenance of homeostasis of self-renewing systems. The paradigms of Notch function, such as stem and progenitor cell maintenance, lineage specification mediated by binary cell fate decisions, and induction of terminal differentiation, were initially established in invertebrates and subsequently confirmed in mammals. Moreover, aberrant Notch signaling is linked to tumorigenesis. In this review, we discuss the origin of postulated Notch functions, give examples from different mammalian organ systems, and try to relate them to the hematopoietic system.
Mots-clé
Animals, Cell Differentiation, Fetal Development/physiology, Humans, Mammals, Receptors, Notch/physiology, Signal Transduction, Stem Cells/physiology
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 15:08
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