Pretherapeutic Motor Thalamus Resting-State Functional Connectivity with Visual Areas Predicts Tremor Arrest After Thalamotomy for Essential Tremor: Tracing the Cerebello-thalamo-visuo-motor Network.

Détails

ID Serval
serval:BIB_A20CC4118DFC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pretherapeutic Motor Thalamus Resting-State Functional Connectivity with Visual Areas Predicts Tremor Arrest After Thalamotomy for Essential Tremor: Tracing the Cerebello-thalamo-visuo-motor Network.
Périodique
World neurosurgery
Auteur(s)
Tuleasca C., Najdenovska E., Régis J., Witjas T., Girard N., Champoudry J., Faouzi M., Thiran J.P., Cuadra M.B., Levivier M., Van De Ville D.
ISSN
1878-8769 (Electronic)
ISSN-L
1878-8750
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
117
Pages
e438-e449
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Essential tremor (ET) is a common movement disorder. Resting-state functional magnetic resonance imaging is a noninvasive neuroimaging method acquired in absence of task.
Our study aimed to correlate pretherapeutic ventrolateral thalamus functional connectivity (FC) with clinical results 1 year after stereotactic radiosurgical thalamotomy (SRS-T) for drug-resistant ET. Data from 12 healthy control individuals were additionally included.
Resting state was acquired for 17 consecutive (right-handed) patients, before and 1 year after left unilateral SRS-T. Standard tremor scores were evaluated pretherapeutically and 1 year after SRS-T. Tremor network was investigated using region of interest, left ventrolateral ventral (VLV) cluster, obtained from pretherapeutic diffusion magnetic resonance imaging. Seed-based FC was obtained as correlations between the time courses of the VLV and that of every other voxel. The seed-connectivity maps were obtained pretherapeutically and correlated across all patients with clinical outcome 1 year after SRS-T. One-year magnetic resonance signature volume was always located inside VLV and did not correlate with reported seed-FC measures (P > 0.05).
We report statistically significant correlations between pretherapeutic VLV FC with clinical outcome for 1) right visual association area (Brodmann area, BA19) predicting 1 year activities of daily living decrease (P <sub>unc</sub>  = 0.02); 2) left fusiform gyrus (BA37) predicting 1 year head tremor score improvement (P <sub>unc</sub>  = 0.04); and 3) posterior cingulate (left BA23, P <sub>uncor</sub>  = 0.009), lateral temporal cortex (right BA21, P <sub>unc</sub>  = 0.02) predicting time to tremor arrest.
Our results suggest that pretherapeutic resting-state seed-FC of left VLV predicts tremor arrest after SRS-T for ET. Visual areas are identified as the main regions in this correlation.
Mots-clé
Activities of Daily Living, Aged, Aged, 80 and over, Cerebellum/physiology, Essential Tremor/radiotherapy, Female, Humans, Magnetic Resonance Imaging/methods, Male, Middle Aged, Motor Cortex/physiology, Neuroimaging/methods, Postoperative Care, Preoperative Care, Radiosurgery/methods, Treatment Outcome, Ventral Thalamic Nuclei/physiopathology, Ventral Thalamic Nuclei/surgery, Visual Cortex/physiology, Essential tremor, Radiosurgery, Resting-state, Seed-based approach, Thalamotomy, Ventrointermediate nucleus, fMRI
Pubmed
Web of science
Création de la notice
16/07/2018 18:02
Dernière modification de la notice
20/08/2019 16:08
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