The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity
Details
Serval ID
serval:BIB_A1C4DAB88657
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity
Journal
Annals of Tropical Medicine and Parasitology
ISSN
0003-4983 (Print)
Publication state
Published
Issued date
08/1995
Volume
89
Number
4
Pages
359-76
Notes
Journal Article
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Aug
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Aug
Abstract
The epidemiological features of malaria were studied through seven community-based surveys in a population of 4000 in the Wosera area, East Sepik Province, Papua New Guinea. Prevalence of parasitaemia (all species, all ages) was 60%. Plasmodium falciparum was the predominant species in all surveys (55%), followed by P. vivax (25%) and P. malariae (20%). The highest prevalence for asexual forms of P. falciparum occurred in the 5-9-year age group, whereas P. falciparum gametocytaemia and P. vivax parasitaemia were observed most frequently in the 1-4-year age group and P. malariae in the 10-15-year age group. Mean densities of all species decreased with age except for that of P. malariae, which was lower in children aged < 1 year than in those aged 1-4 years. The prevalence of enlarged spleen was 57% in children and 10% in adults and closely matched the corresponding age-related parasite rate. Seroprevalence of antibody to the major merozoite surface antigen 2 rapidly increased with age, with > 90% of individuals older than 5 years being positive. Malariological indices showed irregular changes over time but there was no clear-cut seasonal pattern. The geographical distribution of these indices and immune responses was not uniform within the study area. Bednet use and drug consumption were negatively correlated with malariometric indices. Identification of significant temporal and local variations in malaria endemicity is important for the design and evaluation of intervention studies, including field trials of an antimalarial vaccine.
Keywords
Adolescent
Adult
Age Factors
Antibodies, Protozoan/analysis
Child
Child, Preschool
Chloroquine/therapeutic use
Female
Humans
Infant
Malaria/*epidemiology/immunology/prevention & control
Malaria, Falciparum/epidemiology
Male
Mosquito Control
Papua New Guinea/epidemiology
Prevalence
Seasons
Splenomegaly/epidemiology
Pubmed
Web of science
Create date
28/01/2008 12:49
Last modification date
20/08/2019 16:07