Article: article from journal or magazin.
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Therapeutic cancer vaccines based on molecularly defined human tumor antigens.
20 Suppl 4
Publication types: Journal Article - Publication Status: ppublish
The results of numerous phases I and II clinical trials testing the safety and immunogenicity of various cancer vaccine formulations based on cytolytic T lymphocytes (CTLs)-defined tumor antigens have been reported recently. Specific T cell responses can be detected in only a fraction of immunized patients. A smaller but significant fraction of these patients have objective tumor responses. Efficient therapeutic vaccination should aim at boosting naturally occurring anti-tumor responses and at sustaining a large contingent of tumor antigen-specific and fully functional effector T cells at tumor sites.
Antigens, Neoplasm, Cancer Vaccines, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Humans, T-Lymphocytes, Cytotoxic
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