Promises and limitations of murine models in the development of anticancer T-cell vaccines
Details
Serval ID
serval:BIB_A16B46FC5334
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Promises and limitations of murine models in the development of anticancer T-cell vaccines
Journal
International Reviews of Immunology
ISSN
0883-0185 (Print)
Publication state
Published
Issued date
12/2006
Volume
25
Number
5-6
Pages
269-95
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep-Dec
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep-Dec
Abstract
Murine models have been instrumental in defining the basic mechanisms of antitumor immunity. Most of these mechanisms have since been shown to operate in humans as well. Based on these similarities, active vaccination strategies aimed at eliciting antitumor T-cell responses have been elaborated and successfully implemented in various mouse models. However, the results of human antitumor vaccination trials have been rather disappointing thus far. This review summarizes the different experimental approaches used in mice to induce antitumor T-cell responses and identifies some critical parameters that should be considered when evaluating results from murine models.
Keywords
Adjuvants, Immunologic/pharmacology
Animals
Antigens, Neoplasm/*immunology
Cancer Vaccines/immunology/*therapeutic use
Clinical Trials
*Disease Models, Animal
Humans
Immunologic Surveillance
Mice
Neoplasms/*immunology/prevention & control/therapy
T-Cell Antigen Receptor Specificity/*immunology
T-Lymphocytes, Cytotoxic
Pubmed
Web of science
Create date
28/01/2008 12:17
Last modification date
20/08/2019 16:07