Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila.

Détails

Ressource 1Télécharger: e17879-download.pdf (2972.67 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_A162FCD49C54
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila.
Périodique
eLife
Auteur(s)
Knecht Z.A., Silbering A.F., Ni L., Klein M., Budelli G., Bell R., Abuin L., Ferrer A.J., Samuel A.D., Benton R., Garrity P.A.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Statut éditorial
Publié
Date de publication
22/09/2016
Peer-reviewed
Oui
Volume
5
Pages
17879
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection, recent work has implicated two family members, IR21a and IR25a, in thermosensation in Drosophila. Here we characterize one of the most evolutionarily deeply conserved receptors, IR93a, and show that it is co-expressed and functions with IR21a and IR25a to mediate physiological and behavioral responses to cool temperatures. IR93a is also co-expressed with IR25a and a distinct receptor, IR40a, in a discrete population of sensory neurons in the sacculus, a multi-chambered pocket within the antenna. We demonstrate that this combination of receptors is required for neuronal responses to dry air and behavioral discrimination of humidity differences. Our results identify IR93a as a common component of molecularly and cellularly distinct IR pathways important for thermosensation and hygrosensation in insects.

Pubmed
Web of science
Open Access
Oui
Création de la notice
29/09/2016 18:35
Dernière modification de la notice
20/08/2019 15:07
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