Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior.

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ID Serval
serval:BIB_A148E50B94B8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior.
Périodique
Nature Neuroscience
Auteur(s)
Labouèbe G., Boutrel B., Tarussio D., Thorens B.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
2016
Volume
19
Numéro
8
Pages
999-1002
Langue
anglais
Résumé
Feeding behavior is governed by homeostatic needs and motivational drive to obtain palatable foods. Here, we identify a population of glutamatergic neurons in the paraventricular thalamus of mice that express the glucose transporter Glut2 (encoded by Slc2a2) and project to the nucleus accumbens. These neurons are activated by hypoglycemia and, in freely moving mice, their activation by optogenetics or Slc2a2 inactivation increases motivated sucrose-seeking but not saccharin-seeking behavior. These neurons may control sugar overconsumption in obesity and diabetes.
Pubmed
Web of science
Création de la notice
06/07/2016 11:36
Dernière modification de la notice
20/08/2019 16:07
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