Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_A10B16679B11
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression.
Périodique
Journal of Translational Medicine
Auteur(s)
Piazzon N., Bernet F., Guihard L., Leonhard W.N., Urfer S., Firsov D., Chehade H., Vogt B., Piergiovanni S., Peters D.J., Bonny O., Constam D.B.
ISSN
1479-5876 (Electronic)
ISSN-L
1479-5876
Statut éditorial
Publié
Date de publication
03/2015
Peer-reviewed
Oui
Volume
13
Pages
103
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid-filled cysts that frequently result in end-stage renal disease. While promising treatment options are in advanced clinical development, early diagnosis and follow-up remain a major challenge. We therefore evaluated the diagnostic value of Fetuin-A as a new biomarker of ADPKD in human urine.
RESULTS: We found that renal Fetuin-A levels are upregulated in both Pkd1 and Bicc1 mouse models of ADPKD. Measurement by ELISA revealed that urinary Fetuin-A levels were significantly higher in 66 ADPKD patients (17.5 ± 12.5 μg/mmol creatinine) compared to 17 healthy volunteers (8.5 ± 3.8 μg/mmol creatinine) or 50 control patients with renal diseases of other causes (6.2 ± 2.9 μg/mmol creatinine). Receiver operating characteristics (ROC) analysis of urinary Fetuin-A levels for ADPKD rendered an optimum cut-off value of 12.2 μg/mmol creatinine, corresponding to 94% of sensitivity and 60% of specificity (area under the curve 0.74 ; p = 0.0019). Furthermore, urinary Fetuin-A levels in ADPKD patients correlated with the degree of renal insufficiency and showed a significant increase in patients with preserved renal function followed for two years.
CONCLUSIONS: Our findings establish urinary Fetuin-A as a sensitive biomarker of the progression of ADPKD. Further studies are required to examine the pathogenic mechanisms of elevated renal and urinary Fetuin-A in ADPKD.
Mots-clé
Adult, Aged, Animals, Biomarkers/urine, Disease Models, Animal, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Humans, Kidney Failure, Chronic/urine, Male, Mice, Knockout, Middle Aged, Polycystic Kidney, Autosomal Dominant/pathology, Polycystic Kidney, Autosomal Dominant/urine, RNA-Binding Proteins/metabolism, ROC Curve, Up-Regulation, alpha-2-HS-Glycoprotein/urine
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/01/2016 9:39
Dernière modification de la notice
20/08/2019 15:07
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