Extended lymphadenectomy in patients with pancreatic cancer is debatable.

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Version: Final published version
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Serval ID
serval:BIB_A10A31AD8130
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Extended lymphadenectomy in patients with pancreatic cancer is debatable.
Journal
World journal of surgery
Author(s)
Sergeant G., Melloul E., Lesurtel M., Deoliveira M.L., Clavien P.A.
ISSN
1432-2323 (Electronic)
ISSN-L
0364-2313
Publication state
Published
Issued date
08/2013
Volume
37
Number
8
Pages
1782-1788
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Lymph node staging is one of the most important factors in determining the prognosis after resection of pancreatic ductal adenocarcinoma. Despite ongoing efforts to further refine lymph node staging, the debate on the extent of lymphadenectomy during pancreaticoduodenectomy is still open. The purpose of this review was to summarize the evidence about performing standard lymphadenectomy during curative resection of pancreatic cancer. All four prospective randomized controlled trials published concluded that extended lymphadenectomy does not contribute to better oncologic outcome for patients with adenocarcinoma of the pancreatic head. Indeed, one major drawback of extended lymphadenectomy is the higher risk of persistent postoperative diarrhea. No prospective randomized studies could be found on the role of extended lymphadenectomy in patients with adenocarcinoma of the corpus and tail. Based on current evidence there is no indication that extended lymphadenectomy should be performed routinely during resection of pancreatic cancer.
Keywords
Clinical Trials as Topic, Humans, Lymph Node Excision/methods, Lymphatic Metastasis, Neoplasm Recurrence, Local, Pancreatic Neoplasms/pathology, Pancreatic Neoplasms/surgery
Pubmed
Open Access
Yes
Create date
15/02/2017 10:44
Last modification date
11/04/2023 9:50
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