Article: article from journal or magazin.
Influence of interferon beta-1a dose frequency on PBMC cytokine secretion and biological effect markers.
Journal of Neuroimmunology
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Interferon-beta regimens for immune-mediated diseases, such as multiple sclerosis (MS), have not been compared regarding their biological effects. In this randomized, parallel-group, placebo-controlled study, cytokine secretion by mitogen-stimulated PBMCs and serum response markers were assessed in volunteers receiving subcutaneous recombinant IFN beta-1a (Rebif, Ares-Serono) 22 microg once a week (QW), 22 microg three times a week, 66 microg QW, or placebo. The production of IL-1beta, IL-6, IFN-gamma, TNF-alpha and TNF-beta markedly decreased during 24-48 h after each injection, with limited dose-dependency and no evidence of tolerance or effect augmentation over 1 month. IL-10 secretion remained unchanged. The increase in serum beta2-microglobulin, neopterin and 2-5A-synthetase was more sustained. Thus, IFN-beta-induced immunomodulation in vivo strongly depends on the administration schedule, the time-integrated effect being 2-3 times greater when a same weekly dose is divided in three injections.
2',5'-Oligoadenylate Synthetase/blood, Adult, Dose-Response Relationship, Immunologic, Drug Administration Schedule, Fatigue/chemically induced, Fever/chemically induced, Headache/chemically induced, Humans, Immunologic Factors/administration & dosage, Immunologic Factors/adverse effects, Interferon-beta/administration & dosage, Interferon-beta/adverse effects, Interferon-gamma/secretion, Interleukin-1/secretion, Interleukin-6/secretion, Lymphocyte Activation/drug effects, Lymphokines/secretion, Lymphotoxin-alpha/secretion, Male, Neopterin/blood, Recombinant Proteins/administration & dosage, Recombinant Proteins/adverse effects, Safety, T-Lymphocytes/drug effects, T-Lymphocytes/secretion, Tumor Necrosis Factor-alpha/secretion, beta 2-Microglobulin/analysis
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