Orthopedic implant used as drug delivery system: clinical situation and state of the research.

Détails

ID Serval
serval:BIB_A0D5DA5A8E4D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Orthopedic implant used as drug delivery system: clinical situation and state of the research.
Périodique
Current Drug delivery
Auteur(s)
Pioletti D.P., Gauthier O., Stadelmann V.A., Bujoli B., Guicheux J., Zambelli P.Y., Bouler J.M.
ISSN
1567-2018
Statut éditorial
Publié
Date de publication
2008
Volume
5
Numéro
1
Pages
59-63
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part, an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondly, a review of the clinical situation is developed for implants already used as drug delivery system. Experimental works performed for local delivery are reported. In particular, a description is given on the in vitro and in vivo studies where the implant is coated with different proteins or drugs. Finally, a conclusion is proposed on the next step in the development of orthopedic implant as drug delivery system mentioning also the industrial situation.
Mots-clé
Biocompatible Materials, Drug Delivery Systems, Drug Implants, Humans, Orthopedic Equipment, Orthopedic Fixation Devices, Prostheses and Implants
Pubmed
Création de la notice
05/03/2009 18:19
Dernière modification de la notice
20/08/2019 15:06
Données d'usage