Investigating the functions of subregions within anterior hippocampus.

Détails

Ressource 1Télécharger: BIB_A09651F61D3A.P001.pdf (2327.25 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_A09651F61D3A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Investigating the functions of subregions within anterior hippocampus.
Périodique
Cortex; A Journal Devoted To the Study of the Nervous System and Behavior
Auteur(s)
Zeidman P., Lutti A., Maguire E.A.
ISSN
1973-8102 (Electronic)
ISSN-L
0010-9452
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
73
Pages
240-256
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Previous functional MRI (fMRI) studies have associated anterior hippocampus with imagining and recalling scenes, imagining the future, recalling autobiographical memories and visual scene perception. We have observed that this typically involves the medial rather than the lateral portion of the anterior hippocampus. Here, we investigated which specific structures of the hippocampus underpin this observation. We had participants imagine novel scenes during fMRI scanning, as well as recall previously learned scenes from two different time periods (one week and 30 min prior to scanning), with analogous single object conditions as baselines. Using an extended segmentation protocol focussing on anterior hippocampus, we first investigated which substructures of the hippocampus respond to scenes, and found both imagination and recall of scenes to be associated with activity in presubiculum/parasubiculum, a region associated with spatial representation in rodents. Next, we compared imagining novel scenes to recall from one week or 30 min before scanning. We expected a strong response to imagining novel scenes and 1-week recall, as both involve constructing scene representations from elements stored across cortex. By contrast, we expected a weaker response to 30-min recall, as representations of these scenes had already been constructed but not yet consolidated. Both imagination and 1-week recall of scenes engaged anterior hippocampal structures (anterior subiculum and uncus respectively), indicating possible roles in scene construction. By contrast, 30-min recall of scenes elicited significantly less activation of anterior hippocampus but did engage posterior CA3. Together, these results elucidate the functions of different parts of the anterior hippocampus, a key brain area about which little is definitely known.
Mots-clé
Adult, Brain Mapping/methods, Female, Hippocampus/physiology, Humans, Imagination/physiology, Magnetic Resonance Imaging/methods, Male, Memory, Episodic, Mental Recall/physiology, Parahippocampal Gyrus/physiology, Space Perception/physiology, Visual Perception/physiology, Young Adult
Pubmed
Web of science
Création de la notice
19/02/2016 19:47
Dernière modification de la notice
15/03/2019 14:05
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