Developmental stability in house mice heterozygous for single Robertsonian fusions.

Détails

ID Serval
serval:BIB_A040A1257BE3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Developmental stability in house mice heterozygous for single Robertsonian fusions.
Périodique
Journal of Heredity
Auteur(s)
Auffray J.C., Fontanillas P., Catalan J., Britton-Davidian J.
ISSN
0022-1503 (Print)
ISSN-L
0022-1503
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
92
Numéro
1
Pages
23-29
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Fluctuating asymmetry (FA) of tooth traits has been reported to be increased in Down syndrome patients as well as hybrids between chromosomal races of the house mouse differing in several Robertsonian (Rb) fusions. Developmental stability, assessed by FA, is thus thought to be impaired by spontaneous chromosomal abnormality or by chromosomal heterozygosity. Although the effect of a single fusion on developmental stability could theoretically be expected, it has never been documented. Crosses involving two chromosomal races of the house mouse diverging for one Rb fusion were performed to assess developmental stability in parental homozygous races as well as in their hybrids. Moreover, the occurrence of a spontaneous chromosomal mutation (WART type-b) allowed us to study the instantaneous effect of such a translocation on developmental stability. No difference in fluctuating asymmetry levels was detected among the groups considered in this study. This result suggested that a single stable or spontaneous balanced structural rearrangement did not inherently disturb developmental stability. In addition, the differential effect on developmental stability of one versus many heterozygous Rb fusions highlights the role of their quantitative accumulation in the disruption of coadaptation in chromosomal hybrids.
Mots-clé
Animals, Centromere, Chromosome Aberrations, Chromosome Banding, Chromosome Disorders, Crosses, Genetic, Female, Heterozygote, In Situ Hybridization, Fluorescence, Male, Mice/genetics, Models, Genetic, Mosaicism, Mutation, Tooth/growth & development, Translocation, Genetic
Pubmed
Création de la notice
23/02/2009 14:00
Dernière modification de la notice
20/08/2019 15:06
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