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Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation.
Microbes and Infection
Nuclear factor of activated T (NFAT) cells is a family of transcription factors important for the regulation of cytokine expression by CD4+ T cells. Whilst a number of studies have examined NFAT activity of in vitro generated CD4+ T helper (Th)1 and Th2 cells, regulation of NFAT during in vivo immune responses has yet to be elucidated. We show that NFAT activity in CD4+ T cells peaked at early time-points in the draining mediastinal lymph node of mice infected with influenza A (Flu) or Nippostrongylus brasiliensis (Nb). In contrast, low NFAT transcriptional activity was detected in CD4+ T cells isolated from the lung of either Flu or Nb infected mice, despite a greater proportion of cytokine-producing cells being present at this site. These findings indicate that the activation status and tissue microenvironment of effector CD4+ T cells can determine their requirement for NFAT-mediated transcription.
Animals, DNA/metabolism, Influenza A virus/immunology, Influenza A virus/physiology, Lung/cytology, Lymph Nodes/cytology, Lymphocyte Activation, Mice, NFATC Transcription Factors/metabolism, Nippostrongylus, Organ Specificity, Orthomyxoviridae Infections/metabolism, Orthomyxoviridae Infections/virology, Protein Binding, Strongylida Infections/genetics, Strongylida Infections/immunology, Th1 Cells/cytology, Th1 Cells/immunology, Th2 Cells/cytology, Th2 Cells/immunology, Transcription, Genetic
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