Choanoflagellates and the ancestry of neurosecretory vesicles.

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License: CC BY 4.0
Serval ID
serval:BIB_9FD78DB680AA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Choanoflagellates and the ancestry of neurosecretory vesicles.
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Author(s)
Göhde R., Naumann B., Laundon D., Imig C., McDonald K., Cooper B.H., Varoqueaux F., Fasshauer D., Burkhardt P.
ISSN
1471-2970 (Electronic)
ISSN-L
0962-8436
Publication state
Published
Issued date
29/03/2021
Peer-reviewed
Oui
Volume
376
Number
1821
Pages
20190759
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Neurosecretory vesicles are highly specialized trafficking organelles that store neurotransmitters that are released at presynaptic nerve endings and are, therefore, important for animal cell-cell signalling. Despite considerable anatomical and functional diversity of neurons in animals, the protein composition of neurosecretory vesicles in bilaterians appears to be similar. This similarity points towards a common evolutionary origin. Moreover, many putative homologues of key neurosecretory vesicle proteins predate the origin of the first neurons, and some even the origin of the first animals. However, little is known about the molecular toolkit of these vesicles in non-bilaterian animals and their closest unicellular relatives, making inferences about the evolutionary origin of neurosecretory vesicles extremely difficult. By comparing 28 proteins of the core neurosecretory vesicle proteome in 13 different species, we demonstrate that most of the proteins are present in unicellular organisms. Surprisingly, we find that the vesicular membrane-associated soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein synaptobrevin is localized to the vesicle-rich apical and basal pole in the choanoflagellate Salpingoeca rosetta. Our 3D vesicle reconstructions reveal that the choanoflagellates S. rosetta and Monosiga brevicollis exhibit a polarized and diverse vesicular landscape reminiscent of the polarized organization of chemical synapses that secrete the content of neurosecretory vesicles into the synaptic cleft. This study sheds light on the ancestral molecular machinery of neurosecretory vesicles and provides a framework to understand the origin and evolution of secretory cells, synapses and neurons. This article is part of the theme issue 'Basal cognition: multicellularity, neurons and the cognitive lens'.
Keywords
SNARE, cell polarity, choanoflagellate, evolution, synaptobrevin, vesicle
Pubmed
Open Access
Yes
Create date
22/02/2021 14:34
Last modification date
12/01/2022 7:12
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