Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE.

Details

Serval ID
serval:BIB_9FD1167445C7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE.
Journal
AJNR. American journal of neuroradiology
Author(s)
Beck E.S., Sati P., Sethi V., Kober T., Dewey B., Bhargava P., Nair G., Cortese I.C., Reich D.S.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
39
Number
3
Pages
459-466
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
Publication Status: ppublish
Abstract
Cortical lesions are common and often extensive in multiple sclerosis but are difficult to visualize by MRI, leaving important questions about their clinical implications and response to therapy unanswered. Our aim was to determine whether cortical lesions are better visualized using magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) than T2*-weighted imaging on 7T MR imaging.
Brain MR imaging using T1-weighted MP2RAGE at 500-μm isotropic resolution, T2*-weighted gradient-echo, and T2*-weighted segmented echo-planar imaging sequences were collected for 13 patients with MS and 5 age-matched neurologically healthy controls on a 7T research system. One MS case underwent postmortem MR imaging including gradient-echo and MP2RAGE sequences, after which cortical lesions seen on MR imaging were assessed with immunohistochemistry.
MP2RAGE detected 203 cortical lesions (median, 16 lesions/case; interquartile range, 15), compared to 92 with T2*gradient-echo (median, 7; interquartile range, 8; P < .001) and 81 with T2*EPI (median, 7; interquartile range, 5; P < .001). This increase in lesion number detected on MP2RAGE versus T2* was observed for juxtacortical, leukocortical, and intracortical lesions. Forty-three percent of all cortical lesions were identified only on MP2RAGE. White matter lesion volume correlated with total juxtacortical (r = 0.86, P < .001) and leukocortical lesion volume (r = 0.70, P < .01) but not intracortical lesion volume, suggesting that pathophysiology may differ by lesion type. Of 4 suspected lesions seen on postmortem imaging, 3 were found to be true cortical lesions while 1 represented postmortem tissue damage.
A combination of MP2RAGE and T2*-weighted imaging at 7T improved detection of cortical lesions and should enable longitudinal studies to elucidate their spatiotemporal dynamics and clinical implications.
Keywords
Adult, Cerebral Cortex/diagnostic imaging, Cerebral Cortex/pathology, Echo-Planar Imaging/methods, Female, Humans, Magnetic Resonance Imaging/methods, Male, Middle Aged, Multiple Sclerosis/diagnostic imaging, Multiple Sclerosis/pathology, Neuroimaging/methods, White Matter/diagnostic imaging, White Matter/pathology
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2018 18:43
Last modification date
20/08/2019 15:06
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