Interferences in the measurement of circulating phosphate: a literature review.
Details
Serval ID
serval:BIB_9FC269D77391
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interferences in the measurement of circulating phosphate: a literature review.
Journal
Clinical chemistry and laboratory medicine
ISSN
1437-4331 (Electronic)
ISSN-L
1434-6621
Publication state
Published
Issued date
26/11/2020
Peer-reviewed
Oui
Volume
58
Number
12
Pages
1971-1977
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Background Inorganic phosphate in blood is currently determined by the reaction with molybdate. This report aims at reviewing conditions underlying spuriously altered levels of circulating inorganic phosphate. Content A systematic search of the Excerpta Medica, the National Library Database and the Web of Science database was conducted without language restriction from the earliest publication date available through January 31, 2020. Summary For the analysis, 80 reports published in English (n = 77), French (n = 1), German (n = 1) and Spanish (n = 1) were retained. Well-documented pseudohyperphosphatemia was observed in individuals exposed to liposomal amphotericin, in patients affected by a gammopathy, in patients with hyperlipidemia and in patients with hyperbilirubinemia. An unexplained elevated inorganic phosphate level sometimes provided a clue to the diagnosis of a gammopathy. Well-documented cases of pseudohypophosphatemia were observed in patients on large amounts of intravenous mannitol. Finally, pseudohypophosphatemia was occasionally observed on treatment with liposomal amphotericin and in patients with a gammopathy. Outlook In order to avoid unnecessary testing and treatment, the phenomenon of spuriously altered inorganic phosphate should be recognized. An unexplained hyperphosphatemia may provide a clue to the diagnosis of a gammopathy or a severe hyperlipidemia.
Keywords
Humans, Hyperphosphatemia/blood, Hyperphosphatemia/diagnosis, Hypophosphatemia/blood, Hypophosphatemia/diagnosis, Molybdenum/blood, Molybdenum/chemistry, Multiple Myeloma/blood, Multiple Myeloma/diagnosis, Phosphates/analysis, Phosphates/blood, amphotericin B, dyselectrolytemia, electrolytes, gammopathy, hyperlipidemia, inorganic phosphate
Pubmed
Web of science
Open Access
Yes
Create date
06/07/2020 13:31
Last modification date
20/02/2024 7:17