Prediction of Glioma Grade and IDH Status Using <sup>18</sup>F-FET PET/CT Dynamic and Multiparametric Texture Analysis.
Details
Serval ID
serval:BIB_9F508F3C03E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prediction of Glioma Grade and IDH Status Using <sup>18</sup>F-FET PET/CT Dynamic and Multiparametric Texture Analysis.
Journal
Diagnostics
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Publication state
Published
Issued date
05/08/2023
Peer-reviewed
Oui
Volume
13
Number
15
Pages
2604
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Mutations in isocitrate dehydrogenase (IDH) represent an independent predictor of better survival in patients with gliomas. We aimed to assess grade and IDH mutation status in patients with untreated gliomas, by evaluating the respective value of <sup>18</sup> F-FET PET/CT via dynamic and texture analyses. A total of 73 patients (male: 48, median age: 47) who underwent an <sup>18</sup> F-FET PET/CT for initial glioma evaluation were retrospectively included. IDH status was available in 61 patients (20 patients with WHO grade 2 gliomas, 41 with grade 3-4 gliomas). Time-activity curve type and 20 parameters obtained from static analysis using LIFEx© v6.30 software were recorded. Respective performance was assessed using receiver operating characteristic curve analysis and stepwise multivariate regression analysis adjusted for patients' age and sex. The time-activity curve type and texture parameters derived from the static parameters showed satisfactory-to-good performance in predicting glioma grade and IDH status. Both time-activity curve type (stepwise OR: 101.6 (95% CI: 5.76-1791), p = 0.002) and NGLDM coarseness (stepwise OR: 2.08 × 10 <sup>43</sup> (95% CI: 2.76 × 10 <sup>12</sup> -1.57 × 10 <sup>74</sup> ), p = 0.006) were independent predictors of glioma grade. No independent predictor of IDH status was found. Dynamic and texture analyses of <sup>18</sup> F-FET PET/CT have limited predictive value for IDH status when adjusted for confounding factors. However, they both help predict glioma grade.
Keywords
18f-fet pet, IDH mutational status, gliomas, radiomics, texture analysis, 18F-FET PET
Pubmed
Web of science
Open Access
Yes
Create date
21/08/2023 8:44
Last modification date
08/08/2024 7:25