Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.

Détails

ID Serval
serval:BIB_9F3BC8E83049
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.
Périodique
Science
Auteur(s)
Vegiopoulos A., Müller-Decker K., Strzoda D., Schmitt I., Chichelnitskiy E., Ostertag A., Berriel Diaz M., Rozman J., Hrabe de Angelis M., Nüsing R.M., Meyer C.W., Wahli W., Klingenspor M., Herzig S.
ISSN
1095-9203[electronic], 0036-8075[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
328
Numéro
5982
Pages
1158-1161
Langue
anglais
Résumé
Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive thermogenesis. Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic signaling in WAT and is required for the induction of BAT in WAT depots. PG shifted the differentiation of defined mesenchymal progenitors toward a brown adipocyte phenotype. Overexpression of COX-2 in WAT induced de novo BAT recruitment in WAT, increased systemic energy expenditure, and protected mice against high-fat diet-induced obesity. Thus, COX-2 appears integral to de novo BAT recruitment, which suggests that the PG pathway regulates systemic energy homeostasis.
Mots-clé
Adipocytes, Brown/cytology, Adipocytes, Brown/physiology, Adipogenesis, Adipose Tissue, Adipose Tissue, Brown/cytology, Adipose Tissue, Brown/physiology, Adipose Tissue, White/enzymology, Adipose Tissue, White/physiology, Adrenergic beta-3 Receptor Agonists, Adrenergic beta-Agonists/pharmacology, Animals, Body Weight, Cyclooxygenase 2/genetics, Cyclooxygenase 2/metabolism, Dietary Fats/administration & dosage, Dioxoles/pharmacology, Energy Metabolism, Female, Gene Expression Regulation, Enzymologic, Homeostasis, Male, Mesenchymal Stem Cells/cytology, Mice, Mice, Inbred C57BL, Mice, Obese, Mice, Transgenic, Norepinephrine/metabolism, Obesity/etiology, Obesity/prevention & control, Oxygen Consumption, Prostaglandins/metabolism, Receptors, Adrenergic, beta-3/metabolism, Signal Transduction, Thermogenesis
Pubmed
Web of science
Création de la notice
10/03/2011 13:00
Dernière modification de la notice
03/03/2018 20:02
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