Nucleosome arcs and helices

Détails

ID Serval
serval:BIB_9F1F4178E895
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Nucleosome arcs and helices
Périodique
Science
Auteur(s)
Dubochet  J., Noll  M.
ISSN
0036-8075 (Print)
Statut éditorial
Publié
Date de publication
10/1978
Volume
202
Numéro
4365
Pages
280-6
Notes
Journal Article --- Old month value: Oct 20
Résumé
Crystals and other regular arrangements of nucleosome cores have been obtained and analyzed in the electron microscope. Two types of regular structures have been studied in detail, the nucleosome arcs and cylinders. The latter are composed of concentric cylindrical layers of intertwined right-handed helices of nucleosome cores. These studies lead to the following conclusions and concepts. The overall structure of the nucleosome core is a short, wedge-shaped cylinder measuring about 110 by 110 by 60 angstroms. Nucleosome cores interact primarily between top and bottom planes. Nucleosome cores exhibit large conformational variability. A pivot allowing two degrees of rotational freedom is postulated in the region of the 70th base pair to account for this property of the nucleosome.
Mots-clé
Animals Chromatin/*ultrastructure Crystallography Macromolecular Substances Micrococcal Nuclease/metabolism Microscopy, Electron/methods Rats
Pubmed
Web of science
Création de la notice
24/01/2008 11:25
Dernière modification de la notice
03/03/2018 20:02
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