Demyelination of superficial white matter in early Alzheimer's disease: a magnetization transfer imaging study.

Détails

ID Serval
serval:BIB_9F01C2E8D7E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Demyelination of superficial white matter in early Alzheimer's disease: a magnetization transfer imaging study.
Périodique
Neurobiology of Aging
Auteur(s)
Fornari E., Maeder P., Meuli R., Ghika J., Knyazeva M.G.
ISSN
0197-4580
ISSN-L
0197-4580
Statut éditorial
Publié
Date de publication
2012
Volume
33
Numéro
2
Pages
428.e7-428.e19
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Assuming selective vulnerability of short association U-fibers in early Alzheimer's disease (AD), we quantified demyelination of the surface white matter (dSWM) with magnetization transfer ratio (MTR) in 15 patients (Clinical Dementia Rating Scale [CDR] 0.5-1; Functional Assessment Staging [FAST]: 3-4) compared with 15 controls. MTRs were computed for 39 areas in each hemisphere. We found a bilateral MTR decrease in the temporal, cingulate, parietal, and prefrontal areas. With linear discriminant analysis, we successfully classified all the participants with 3 variates including the cuneus, parahippocampal, and superior temporal regions of the left hemisphere. The pattern of dSWM changed with the age of AD onset. In early onset patients, we found bilateral posterior demyelination spreading to the temporal areas in the left hemisphere. The late onset patients showed a distributed bilateral pattern with the temporal and cingulate areas strongly affected. A correlation with Mini Mental State Examination (MMSE), Lexis, and memory tests revealed the dSWM impact on cognition. A specific landscape of dSWM in early AD shows the potential of MTR imaging as an in vivo biomarker superior to currently used techniques.
Pubmed
Web of science
Création de la notice
05/01/2011 15:42
Dernière modification de la notice
03/03/2018 20:01
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