Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy: Which Threshold Is the Best Predictor of Local Control?

Détails

ID Serval
serval:BIB_9E7E6BC7209D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy: Which Threshold Is the Best Predictor of Local Control?
Périodique
Clinical nuclear medicine
Auteur(s)
Castelli J., Depeursinge A., de Bari B., Devillers A., de Crevoisier R., Bourhis J., Prior J.O.
ISSN
1536-0229 (Electronic)
ISSN-L
0363-9762
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
42
Numéro
6
Pages
e281-e285
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In the context of oropharyngeal cancer treated with definitive radiotherapy, the aim of this retrospective study was to identify the best threshold value to compute metabolic tumor volume (MTV) and/or total lesion glycolysis to predict local-regional control (LRC) and disease-free survival.
One hundred twenty patients with a locally advanced oropharyngeal cancer from 2 different institutions treated with definitive radiotherapy underwent FDG PET/CT before treatment. Various MTVs and total lesion glycolysis were defined based on 2 segmentation methods: (i) an absolute threshold of SUV (0-20 g/mL) or (ii) a relative threshold for SUVmax (0%-100%). The parameters' predictive capabilities for disease-free survival and LRC were assessed using the Harrell C-index and Cox regression model.
Relative thresholds between 40% and 68% and absolute threshold between 5.5 and 7 had a similar predictive value for LRC (C-index = 0.65 and 0.64, respectively). Metabolic tumor volume had a higher predictive value than gross tumor volume (C-index = 0.61) and SUVmax (C-index = 0.54). Metabolic tumor volume computed with a relative threshold of 51% of SUVmax was the best predictor of disease-free survival (hazard ratio, 1.23 [per 10 mL], P = 0.009) and LRC (hazard ratio: 1.22 [per 10 mL], P = 0.02).
The use of different thresholds within a reasonable range (between 5.5 and 7 for an absolute threshold and between 40% and 68% for a relative threshold) seems to have no major impact on the predictive value of MTV. This parameter may be used to identify patient with a high risk of recurrence and who may benefit from treatment intensification.

Mots-clé
Adult, Aged, Disease-Free Survival, Female, Fluorodeoxyglucose F18/metabolism, Glycolysis, Humans, Male, Middle Aged, Oropharyngeal Neoplasms/diagnostic imaging, Oropharyngeal Neoplasms/metabolism, Oropharyngeal Neoplasms/pathology, Oropharyngeal Neoplasms/radiotherapy, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Proportional Hazards Models, Retrospective Studies, Tumor Burden
Pubmed
Web of science
Création de la notice
21/03/2017 18:10
Dernière modification de la notice
20/08/2019 15:04
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