DNA sequence comparison between two tissue-specific variants of the autonomous parvovirus, minute virus of mice

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Serval ID
serval:BIB_9E71EC0CB95D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
DNA sequence comparison between two tissue-specific variants of the autonomous parvovirus, minute virus of mice
Journal
Nucleic Acids Research
Author(s)
Sahli  R., McMaster  G. K., Hirt  B.
ISSN
0305-1048 (Print)
Publication state
Published
Issued date
05/1985
Volume
13
Number
10
Pages
3617-33
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 24
Abstract
We have determined the complete nucleotide sequence of the DNA of the immunosuppressive variant of the parvovirus minute virus of mice (MVMi) and compared it to the published sequence (12) of the fibroblast-specific strain (MVMp). We have found 175 differences between the two viruses, most of which affect single nucleotides. Despite these differences, the genomic organization of MVMp and MVMi is identical. There are 29 amino-acid changes between the putative viral gene products of MVMi and MVMp, 16 of which are conservative. We discuss the possibility that the differential tissue-specificity of the two variants is linked to differences within the non-transcribed region near the 5' end of the viral genomes.
Keywords
Animals Base Sequence DNA Replication DNA, Viral/*analysis Genes, Viral Mice Minute virus of mice/*genetics Parvoviridae/*genetics Viral Proteins/analysis
Pubmed
Web of science
Create date
24/01/2008 20:51
Last modification date
20/08/2019 15:04
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