Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight.

Détails

ID Serval
serval:BIB_9E6C78808E97
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight.
Périodique
Cell Metabolism
Auteur(s)
Jimenez-Preitner M., Berney X., Uldry M., Vitali A., Cinti S., Ledford J.G., Thorens B.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Statut éditorial
Publié
Date de publication
2011
Volume
14
Numéro
5
Pages
658-670
Langue
anglais
Résumé
Brown adipocytes oxidize fatty acids to produce heat in response to cold or to excessive energy intake; stimulation of brown fat development and function may thus counteract obesity. Brown adipogenesis requires activation of the transcription factor C/EBPβ and recruitment of the zinc finger protein Prdm16, but upstream inducers of these proteins are incompletely defined. Here, we show that genetic inactivation of Plac8, a gene encoding an evolutionarily conserved protein, induces cold intolerance, and late-onset obesity, as well as abnormal morphology and impaired function of brown adipocytes. Using brown preadipocyte lines we show that Plac8 is required for brown fat differentiation, that its overexpression induces C/EBPβ and Prdm16, and that upon induction of differentiation Plac8 associates with C/EBPβ and binds to the C/EBPβ promoter to induce its transcription. Thus, Plac8 is a critical upstream regulator of brown fat differentiation and function that acts, at least in part, by inducing C/EBPβ expression.
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2012 10:51
Dernière modification de la notice
20/08/2019 16:04
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