Pancreatic stone protein as a postmortem biochemical marker for the diagnosis of sepsis.

Détails

ID Serval
serval:BIB_9DCE3B0B058A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pancreatic stone protein as a postmortem biochemical marker for the diagnosis of sepsis.
Périodique
Legal Medicine
Auteur(s)
Palmiere C., Augsburger M.
ISSN
1344-6223
1873-4162 (Electronic)
ISSN-L
1344-6223
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
9-13
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Pancreatic stone protein/regenerating protein has recently emerged as an interesting diagnostic and prognostic marker of inflammation and sepsis in the clinical field. Increased blood concentrations have been described in patients with sepsis. Moreover, a high accuracy in predicting fatal outcomes in septic patients admitted to intensive care units has been reported. In this study, we investigated pancreatic stone protein/regenerating protein in postmortem serum in a series of sepsis-related fatalities, local infections and non-infectious cases that underwent medico-legal investigations. Procalcitonin, C-reactive protein, interleukin 6, soluble triggering receptor expressed on myeloid cells-1 and pancreatic stone protein/regenerating protein were measured in the postmortem serum collected during autopsy in a group of sepsis-related deaths, local infections and non-septic intensive care unit patients. Statistically significant differences in pancreatic stone protein/regenerating protein concentrations were observed between sepsis and control patients. A significant positive correlation was found between procalcitonin and pancreatic stone protein/regenerating protein values in septic cases. Pancreatic stone protein/regenerating protein is measurable in postmortem serum from femoral blood collected during autopsy. Additionally, as in the clinical field, pancreatic stone protein/regenerating protein can be used as a postmortem biochemical marker for the diagnosis of sepsis.
Pubmed
Web of science
Création de la notice
27/10/2014 13:50
Dernière modification de la notice
20/08/2019 16:04
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