Evaluation of noninvasive blood pressure recording by photoplethysmography in clinical studies using angiotensin challenges

Détails

ID Serval
serval:BIB_9DA1E186FA0B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evaluation of noninvasive blood pressure recording by photoplethysmography in clinical studies using angiotensin challenges
Périodique
British Journal of Clinical Pharmacology
Auteur(s)
Buclin  T., Buchwalder-Csajka  C., Brunner  H. R., Biollaz  J.
ISSN
0306-5251 (Print)
Statut éditorial
Publié
Date de publication
10/1999
Volume
48
Numéro
4
Pages
586-93
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
AIMS: Continuous noninvasive blood pressure measurement by photoplethysmography has been regularly used in the experimental paradigm of angiotensin challenges, applied to the phase I clinical testing of angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists. This work aims to evaluate the performance of this measurement method, in terms of reliability, reproducibility and dependence on technical settings. METHODS: Data have been gathered from 13 clinical studies on antihypertensive drugs, using the Finapres device for measuring the response to exogenous angiotensin challenges. The agreement between simultaneous recordings at different fingers and the influence of the reading method are assessed. A literature review addresses the question of the concordance between results obtained noninvasively and through arterial cannulation. RESULTS: The relative precision of blood pressure monitoring by photoplethysmography allows reproducible determination of angiotensin-induced blood pressure peaks (agreement limits for systolic and diastolic peaks: 12 and 6 mmHg respectively). The reading method influences the results to a similar extent. As compared with blood pressure measured intra-arterially, the difference is usually within limits of clinical acceptability. CONCLUSIONS: In the context of phase I studies using the angiotensin challenges methodology, the reliability and reproducibility of noninvasive blood pressure measurement appear satisfactory, despite the technical limitations of this method. The impact of selected changes in the settings and reading methods is limited.
Mots-clé
Angiotensin II/*antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors/*pharmacology Blood Pressure Determination/*methods Clinical Trials, Phase I Computers Data Collection Dose-Response Relationship, Drug Humans Hypertension/drug therapy Photoplethysmography/methods Receptors, Angiotensin/*antagonists & inhibitors Regression Analysis Reproducibility of Results Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 10:41
Dernière modification de la notice
20/08/2019 15:04
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