Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with (152)Tb-DOTATOC.
Details
Serval ID
serval:BIB_9D479621E0AB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with (152)Tb-DOTATOC.
Journal
Dalton transactions
ISSN
1477-9234 (Electronic)
ISSN-L
1477-9226
Publication state
Published
Issued date
31/10/2017
Peer-reviewed
Oui
Volume
46
Number
42
Pages
14638-14646
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The existence of theragnostic pairs of radionuclides allows the preparation of radiopharmaceuticals for diagnostic and therapeutic purposes. Radiolanthanides, such as (177)Lu, are successfully used for therapeutic purposes; however, a perfect diagnostic match is currently not available for clinical use. A unique, multi-disciplinary study was performed using (152)Tb (T1/2 = 17.5 h, Eβ(+)average = 1140 keV, Iβ(+) = 20.3%), which resulted in the first-in-human PET/CT images with this promising radionuclide. For this purpose, (152)Tb was produced via a spallation process followed by mass separation at ISOLDE, CERN. The chemical separation and quality control, performed at PSI, resulted in a pure product in sufficient yields. Clinical PET phantom studies revealed an increased image noise level, because of the smaller β(+) branching ratio of (152)Tb as compared to standard PET nuclides at matched activity concentrations; however, the expected recovery would be comparable at matched signal-to-noise ratios in clinical PET. (152)Tb was used for labeling DOTATOC, at Zentralklinik Bad Berka, and administered to a patient for a first-in-human clinical study. PET scans were performed over a period of 24 h, allowing the visualization of even small metastases with increased tumor-to-background contrast over time. Based on the results obtained in this work, it can be deduced that PET/CT imaging with (152)Tb-labeled targeting agents has promise for clinical application and may be particularly interesting for pre-therapeutic dosimetry.
Pubmed
Web of science
Create date
19/09/2017 13:41
Last modification date
04/11/2019 15:21