Effect of intravenous calcitonin gene related peptide on ischaemia threshold and coronary stenosis severity in humans
Details
Serval ID
serval:BIB_9D30E551B997
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of intravenous calcitonin gene related peptide on ischaemia threshold and coronary stenosis severity in humans
Journal
Cardiovascular Research
ISSN
0008-6363 (Print)
Publication state
Published
Issued date
08/1993
Volume
27
Number
8
Pages
1477-81
Notes
Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article --- Old month value: Aug
Comparative Study
Controlled Clinical Trial
Journal Article --- Old month value: Aug
Abstract
OBJECTIVE: Calcitonin gene related peptide (CGRP) is a potent vasodilator found in sensory nerve endings in coronary arteries. The effect of intravenous CGRP on myocardial ischaemia, cardiovascular haemodynamics, and epicardial coronary artery stenoses was studied in patients with angina to investigate the possible role of CGRP in the control of vasodilation in the coronary circulation. METHODS: 12 patients (mean age 60 years) performed exercise tests on consecutive days during intravenous infusions of placebo or CGRP (at 50 pmol.min-1). At cardiac catheterisation (6 patients), consecutive 20 min intravenous infusions of placebo and CGRP were given at a fixed heart rate, with measurement of haemodynamic variables and quantitative arteriography. RESULTS: The time to 0.1 mV ST depression increased from 475(SD 245) to 546(193) s (p < 0.05), and time to 0.2 mV ST segment depression, from 634(266) to 694(202) s (p < 0.05), on placebo and CGRP respectively. Rate-pressure product at 0.1 mV ST segment depression was 18,410(4590) and 20,750(7270) mm Hg.min-1 (p < 0.05), and at 0.2 mV ST depression it was 21,510(6470) and 24,080(7380) mm Hg.min-1 (p < 0.01), with placebo and CGRP, respectively. At catheterisation, diastolic blood pressure fell from 93(11) to 83(8) mm Hg (p < 0.05), systemic vascular resistance fell from 26.2(9.4) to 20.7(9.0) units (p < 0.05), and cardiac output increased from 5.94(1.10) to 6.73(1.04) litre.min-1 (p < 0.05), on placebo and CGRP respectively. Minimum luminal diameter increased from 0.66(0.23) to 1.11(0.15) mm (p < 0.01) with CGRP. CONCLUSIONS: Intravenous CGRP is a systemic arterial vasodilator which dilates coronary arteries at the site of atheromatous stenoses and delays the onset of myocardial ischaemia during treadmill exercise testing in patients with chronic stable angina.
Keywords
Aged
Calcitonin Gene-Related Peptide/*pharmacology
Coronary Angiography
Coronary Disease/*drug therapy
Coronary Vessels/drug effects
Exercise Test
Female
Hemodynamic Processes/drug effects
Humans
Male
Middle Aged
Myocardial Ischemia/*prevention & control
Vasodilation
Pubmed
Web of science
Create date
28/01/2008 11:11
Last modification date
20/08/2019 16:03