Advanced gastric cancer: Current treatment landscape and future perspectives.

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Version: author
Serval ID
serval:BIB_9CE953713724
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Advanced gastric cancer: Current treatment landscape and future perspectives.
Journal
World Journal of Gastroenterology
Author(s)
Digklia A., Wagner A.D.
ISSN
2219-2840 (Electronic)
ISSN-L
1007-9327
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
22
Number
8
Pages
2403-2414
Language
english
Abstract
Gastric cancer currently ranks fourth in cancer-related mortality worldwide. In the western world, it is most often diagnosed at an advanced stage, after becoming metastatic at distant sites. Patients with advanced disease (locally advanced or metastatic) have a somber prognosis, with a median overall survival of 10-12 mo, and palliative chemotherapy is the mainstay of treatment. In recent years, novel approaches using inhibition of human epidermal growth factor receptor 2 (HER2) have demonstrated significant improvements in progression-free and overall survival, compared with chemotherapy alone, in first-line treatment of patients with overexpression of HER2. In addition, both second-line chemotherapy and treatment with the vascular endothelial growth factor receptor-inhibitor ramucirumab demonstrated significant benefits in terms of overall survival, compared with best supportive care, in randomized studies. Moreover, ramucirumab in combination with chemotherapy demonstrated further significant benefits in terms of progression-free and overall survival, compared with chemotherapy alone, in second-line treatment for patients with metastatic gastric cancer. A recently published molecular classification of gastric cancer is expected to improve patient stratification and selection for clinical trials and provide a roadmap for future drug development. Nevertheless, despite these developments the prognosis of patients with advanced gastric cancer remains poor. In this review we discuss current standards of care and outline major topics of drug development in gastric cancer.
Pubmed
Web of science
Open Access
Yes
Create date
05/04/2016 17:06
Last modification date
20/08/2019 15:03
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