Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.

Détails

Ressource 1Télécharger: BIB_9CE30F110D2A.P001.pdf (882.85 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_9CE30F110D2A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.
Périodique
Bmj Open
Auteur(s)
Morris R.W., Taylor A.E., Fluharty M.E., Bjørngaard J.H., Åsvold B.O., Elvestad Gabrielsen M., Campbell A., Marioni R., Kumari M., Korhonen T., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen L.L., Skaaby T., Ahluwalia T.V., Treur J.L., Willemsen G., Dale C., Wannamethee S.G., Lahti J., Palotie A., Räikkönen K., McConnachie A., Padmanabhan S., Wong A., Dalgård C., Paternoster L., Ben-Shlomo Y., Tyrrell J., Horwood J., Fergusson D.M., Kennedy M.A., Nohr E.A., Christiansen L., Kyvik K.O., Kuh D., Watt G., Eriksson J.G., Whincup P.H., Vink J.M., Boomsma D.I., Davey Smith G., Lawlor D., Linneberg A., Ford I., Jukema J.W., Power C., Hyppönen E., Jarvelin M.R., Preisig M., Borodulin K., Kaprio J., Kivimaki M., Smith B.H., Hayward C., Romundstad P.R., Sørensen T.I., Munafò M.R., Sattar N.
ISSN
2044-6055 (Electronic)
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
5
Numéro
8
Pages
e008808
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: epublish
Résumé
OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.
DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.
PARTICIPANTS: 148,731 current, former and never-smokers of European ancestry aged ≥ 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).
PRIMARY OUTCOME MEASURES: Waist and hip circumferences, and waist-hip ratio.
RESULTS: The data included up to 66,809 never-smokers, 43,009 former smokers and 38,913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele.
CONCLUSIONS: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.
Mots-clé
Adolescent, Adult, Aged, Body Mass Index, Female, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Obesity, Abdominal/complications, Sex Factors, Smoking/adverse effects, Smoking/genetics, Waist Circumference, Waist-Hip Ratio, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/08/2015 16:00
Dernière modification de la notice
20/08/2019 16:03
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