Function and mechanism of the pyrin inflammasome.

Détails

ID Serval
serval:BIB_9CB85942D08B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Function and mechanism of the pyrin inflammasome.
Périodique
European journal of immunology
Auteur(s)
Heilig R., Broz P.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
02/2018
Peer-reviewed
Oui
Volume
48
Numéro
2
Pages
230-238
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that assembles inflammasome complexes in response to pathogen infections. Mutations in the MEFV gene have been linked to autoinflammatory diseases such as familial Mediterranean fever (FMF) or pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND). Recent insights have now revealed how pyrin is activated during infection, providing a molecular basis for the understanding of such disease-causing mutations in pyrin. Interestingly, pyrin does not directly recognize molecular patterns (pathogen- or host-derived danger molecules), but rather responds to disturbances in cytoplasmic homeostasis caused by the infection. In the case of pyrin, these perturbations, recently defined as 'homeostasis-altering molecular processes' (HAMPs), are processes leading to the inactivation of the RhoA GTPase. This review attempts to combine early observation and findings with the most recent discoveries on how pyrin detects inactivation of RhoA to shed light on the function and mechanism of pyrin activation.
Mots-clé
Animals, Familial Mediterranean Fever/genetics, Familial Mediterranean Fever/immunology, Homeostasis, Humans, Infection/genetics, Infection/immunology, Inflammasomes/metabolism, Pyrin/genetics, Pyroptosis, Sweet Syndrome/genetics, Sweet Syndrome/immunology, rhoA GTP-Binding Protein/metabolism, FMF, Inflammasome, MEFV, Pyrin
Pubmed
Web of science
Création de la notice
23/11/2017 22:16
Dernière modification de la notice
14/12/2018 7:26
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