Neural regulation of pancreatic islet cell mass and function.

Détails

ID Serval
serval:BIB_9CA51BF594BB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Neural regulation of pancreatic islet cell mass and function.
Périodique
Diabetes, Obesity and Metabolism
Auteur(s)
Thorens B.
ISSN
1463-1326 (Electronic)
ISSN-L
1462-8902
Statut éditorial
Publié
Date de publication
2014
Volume
16 Suppl 1
Pages
87-95
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Intracellular glucose signalling pathways control the secretion of glucagon and insulin by pancreatic islet α- and β-cells, respectively. However, glucose also indirectly controls the secretion of these hormones through regulation of the autonomic nervous system that richly innervates this endocrine organ. Both parasympathetic and sympathetic nervous systems also impact endocrine pancreas postnatal development and plasticity in adult animals. Defects in these autonomic regulations impair β-cell mass expansion during the weaning period and β-cell mass adaptation in adult life. Both branches of the autonomic nervous system also regulate glucagon secretion. In type 2 diabetes, impaired glucose-dependent autonomic activity causes the loss of cephalic and first phases of insulin secretion, and impaired suppression of glucagon secretion in the postabsorptive phase; in diabetic patients treated with insulin, it causes a progressive failure of hypoglycaemia to trigger the secretion of glucagon and other counterregulatory hormones. Therefore, identification of the glucose-sensing cells that control the autonomic innervation of the endocrine pancreatic and insulin and glucagon secretion is an important goal of research. This is required for a better understanding of the physiological control of glucose homeostasis and its deregulation in diabetes. This review will discuss recent advances in this field of investigation.
Mots-clé
autonomic nervous system, glucagon, Glut2, hypoglycaemia, insulin, optogenetics, pancreatic islets
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/10/2014 8:18
Dernière modification de la notice
20/08/2019 15:03
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