Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.
Journal of Receptor and Signal Transduction Research
The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the alpha1b-adrenergic receptor. Experimental and computational mutagenesis of the alpha1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.
Adrenergic alpha-Agonists/pharmacology, Animals, Blood Pressure/drug effects, Blood Pressure/physiology, Glucose/metabolism, Homeostasis, Humans, Mice, Mice, Knockout, Phosphorylation, Receptors, Adrenergic, alpha-1/physiology, Signal Transduction
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