The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.

Détails

ID Serval
serval:BIB_9CA1E92EC32E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.
Périodique
Journal of Receptor and Signal Transduction Research
Auteur(s)
Cotecchia S., Björklöf K., Rossier O., Stanasila L., Greasley P., Fanelli F.
ISSN
1079-9893 (Print)
ISSN-L
1079-9893
Statut éditorial
Publié
Date de publication
2002
Volume
22
Numéro
1-4
Pages
1-16
Langue
anglais
Résumé
The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the alpha1b-adrenergic receptor. Experimental and computational mutagenesis of the alpha1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.
Mots-clé
Adrenergic alpha-Agonists/pharmacology, Animals, Blood Pressure/drug effects, Blood Pressure/physiology, Glucose/metabolism, Homeostasis, Humans, Mice, Mice, Knockout, Phosphorylation, Receptors, Adrenergic, alpha-1/physiology, Signal Transduction
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 15:03
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