Combination of dynamic and integral methods for generating reproducible functional CBF images.

Détails

ID Serval
serval:BIB_9C530AD81B4A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Combination of dynamic and integral methods for generating reproducible functional CBF images.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Lammertsma A.A., Cunningham V.J., Deiber M.P., Heather J.D., Bloomfield P.M., Nutt J., Frackowiak R.S., Jones T.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1990
Volume
10
Numéro
5
Pages
675-686
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
A new method to measure regional CBF is presented, applying both dynamic and integral analyses to a dynamic sequence of positron emission tomographic scans collected during and following the administration of H2(15)O (inhalation of C15O2). The dynamic analysis is used to correct continuously monitored arterial whole-blood activity for delay and dispersion relative to tissue scans. An integral analysis including corrections for this delay and dispersion is then used to calculate CBF on a pixel-by-pixel basis. Normal values and reproducibility over a 2-h period are presented, together with the results of validation and simulation studies. The results indicate that the single-tissue compartment model adequately describes the distribution of H2(15)O in the brain, without recourse to postulating a nonexchanging water pool.
Mots-clé
Carbon Radioisotopes/diagnostic use, Cerebrovascular Circulation, Humans, Models, Biological, Models, Statistical, Oxygen Radioisotopes/diagnostic use, Reference Values, Reproducibility of Results, Tomography, Emission-Computed/methods
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/10/2011 21:06
Dernière modification de la notice
08/05/2019 22:41
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