Article: article from journal or magazin.
Combination of dynamic and integral methods for generating reproducible functional CBF images.
Journal of Cerebral Blood Flow and Metabolism
Publication types: Journal ArticlePublication Status: ppublish
A new method to measure regional CBF is presented, applying both dynamic and integral analyses to a dynamic sequence of positron emission tomographic scans collected during and following the administration of H2(15)O (inhalation of C15O2). The dynamic analysis is used to correct continuously monitored arterial whole-blood activity for delay and dispersion relative to tissue scans. An integral analysis including corrections for this delay and dispersion is then used to calculate CBF on a pixel-by-pixel basis. Normal values and reproducibility over a 2-h period are presented, together with the results of validation and simulation studies. The results indicate that the single-tissue compartment model adequately describes the distribution of H2(15)O in the brain, without recourse to postulating a nonexchanging water pool.
Carbon Radioisotopes/diagnostic use, Cerebrovascular Circulation, Humans, Models, Biological, Models, Statistical, Oxygen Radioisotopes/diagnostic use, Reference Values, Reproducibility of Results, Tomography, Emission-Computed/methods
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